ENANTIOSPECIFIC SYNTHESIS OF [(2'S, 3'S)-BIS(HYDROXYMETHYL)AZETIDIN-1-YL] PYRIMIDINE NUCLEOSIDES AS POTENTIAL ANTIVIRAL AGENTS

被引：16

作者：

HOSONO, F

NISHIYAMA, S

YAMAMURA, S

IZAWA, T

KATO, K

TERADA, Y

机构：

[1] KEIO UNIV,FAC SCI & TECHNOL,DEPT CHEM,YOKOHAMA,KANAGAWA 223,JAPAN

[2] MEIJO UNIV,FAC PHARM,TEMPAKU KU,NAGOYA,AICHI 468,JAPAN

来源：

TETRAHEDRON | 1994年 / 50卷 / 47期

关键词：

D O I：

10.1016/S0040-4020(01)89342-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantiospecific synthesis of [(2'S, 3'S)-bis(hydroxymethyl)azetidin-1-yl]pyrimidine nucleosides 22,25, and 27 was achieved via construction of the base on the 1-aminoazetidine 18 prepared from (+)-diethyl-L-tartrate, and they are the first members of a new class of nucleoside analogs in which the oxetane ring in oxetanocin-A 4 is replaced by an azetidine ring linked to a nucleic base through an N-N bond.

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页码：13335 / 13346

页数：12

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