HCG CONTAMINATION OF ALGLUCERASE - CLINICAL IMPLICATIONS IN LOW-DOSE REGIMEN

被引:10
作者
COHEN, Y [1 ]
ELSTEIN, D [1 ]
ABRAHAMOV, A [1 ]
HIRSCH, H [1 ]
ZIMRAN, A [1 ]
机构
[1] SHAARE ZEDEK MED CTR,GAUCHER CLIN,IL-91031 JERUSALEM,ISRAEL
关键词
ALGLUCERASE; HCG; GAUCHER DISEASE;
D O I
10.1002/ajh.2830470317
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Alglucerase (Ceredase) is currently the treatment of choice for patients with symptomatic Gaucher disease. The contamination of this placental enzyme with human chorionic gonadotropin (hCG) has raised concern regarding possible endocrinological complications. We examined 32 patients treated with low-dose alglucerase and 27 untreated patients as controls, and found no significant clinical differences between the two groups: no prepubertal children were affected, no menstrual irregularities were reported, and all hCG levels were well within normal range. Conversely, our finding of a statistically significant difference between the groups underscores the importance of initiating parallel studies of hCG contamination in patients receiving high dose protocol. (C) 1994 Wiley-Liss, Inc.
引用
收藏
页码:235 / 236
页数:2
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