LEVODOPA FAILURE IN CHRONIC MANGANISM

被引：87

作者：

LU, CS

HUANG, CC

CHU, NS

CALNE, DB

机构：

[1] CHANG GUNG MEM HOSP,TAIPEI 10591,TAIWAN

[2] UNIV BRITISH COLUMBIA,CTR NEURODEGENERAT DISORDERS,VANCOUVER,BC,CANADA

来源：

NEUROLOGY | 1994年 / 44卷 / 09期

关键词：

D O I：

10.1212/WNL.44.9.1600

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a placebo-controlled study of levodopa in four patients with extrapyramidal deficits caused by chronic manganese intoxication. Their parkinsonism and dystonia had progressed slowly over a period of 5 years after they left the site of exposure. Initially the patients appeared to respond to levodopa in open observations, but this apparent benefit was not sustained. This short-term, double-blind study indicates that their parkinsonism and dystonia failed to respond to levodopa.

引用

页码：1600 / 1602

页数：3

共 18 条

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