EFFECT OF N-ALPHA-BENZOYL-L-ARGININE ETHYL-ESTER ON CORONARY PERFUSION-PRESSURE IN ISOLATED GUINEA-PIG HEART

被引：9

作者：

THOMAS, G

FARHAT, M

MYERS, AK

RAMWELL, PW

机构：

[1] Georgetown University Medical Center, Department of Physiology, Washington

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 178卷 / 02期

关键词：

BAEE (Nα-Benzoyl L-arginine ethyl ester); EDRF (endothelium-dependent relaxing factor); Heart (guinea pig; isolated);

D O I：

10.1016/0014-2999(90)90484-N

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nα-Benzoyl-L-arginine ethyl ester (BAEE) when compared to L-arginine significantly decreased coronary perfusion pressure of isolated guinea pig heart in a dose dependent and reproducible manner. This effect of BAEE was antagonized by haemoglobin and N-monomethyl L-arginine, both inhibitors of endothelium dependent relaxation. These results support the notion that the mechanism of relaxation elicited by BAEE is due to the generation endothelium dependent relaxing factor (EDRF) like agents. © 1990.

引用

收藏

页码：251 / 254

页数：4

相关论文

共 9 条

[1] NG-METHYLARGININE, AN INHIBITOR OF ENDOTHELIUM-DERIVED NITRIC-OXIDE SYNTHESIS, IS A POTENT PRESSOR AGENT IN THE GUINEA-PIG - DOES NITRIC-OXIDE REGULATE BLOOD-PRESSURE INVIVO [J].

AISAKA, K ;

GROSS, SS ;

GRIFFITH, OW ;

LEVI, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 160 (02) :881-886

[2] THE ROLE OF ENDOTHELIUM IN THE RESPONSES OF VASCULAR SMOOTH-MUSCLE TO DRUGS [J].

FURCHGOTT, RF .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1984, 24 :175-197

[3] BIOSYNTHESIS OF NITRIC-OXIDE FROM L-ARGININE - A PATHWAY FOR THE REGULATION OF CELL-FUNCTION AND COMMUNICATION [J].

MONCADA, S ;

PALMER, RMJ ;

HIGGS, EA .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (11) :1709-1715

[4] VASCULAR ENDOTHELIAL-CELLS SYNTHESIZE NITRIC-OXIDE FROM L-ARGININE [J].

PALMER, RMJ ;

ASHTON, DS ;

MONCADA, S .

NATURE, 1988, 333 (6174) :664-666

[5] ROLE OF ENDOTHELIUM-DERIVED NITRIC-OXIDE IN THE REGULATION OF BLOOD-PRESSURE [J].

REES, DD ;

PALMER, RMJ ;

MONCADA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) :3375-3378

[6] A SPECIFIC INHIBITOR OF NITRIC-OXIDE FORMATION FROM L-ARGININE ATTENUATES ENDOTHELIUM-DEPENDENT RELAXATION [J].

REES, DD ;

PALMER, RMJ ;

HODSON, HF ;

MONCADA, S .

BRITISH JOURNAL OF PHARMACOLOGY, 1989, 96 (02) :418-424

[7] NG-MONOMETHYL L-ARGININE IS A NON-SPECIFIC INHIBITOR OF VASCULAR RELAXATION [J].

THOMAS, G ;

COLE, EA ;

RAMWELL, PW .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 170 (1-2) :123-124

[8] VASCULAR RELAXATION MEDIATED BY HYDROXYLAMINES AND OXIMES - THEIR CONVERSION TO NITRITES AND MECHANISM OF ENDOTHELIUM DEPENDENT VASCULAR RELAXATION [J].

THOMAS, G ;

RAMWELL, PW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (02) :889-893

[9] VASODILATORY PROPERTIES OF MONO-L-ARGININE-CONTAINING COMPOUNDS [J].

THOMAS, G ;

RAMWELL, PW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (01) :332-338