INHIBITION OF ADENOSINE RESPONSES OF RAT HIPPOCAMPAL-NEURONS BY NIFEDIPINE AND BAYK-8644

被引：4

作者：

BARTRUP, JT ^{[1
]}

STONE, TW ^{[1
]}

机构：

[1] UNIV GLASGOW,DEPT PHARMACOL,GLASGOW G12 8QQ,SCOTLAND

来源：

BRAIN RESEARCH | 1990年 / 525卷 / 02期

基金：

英国惠康基金;

关键词：

Adenosine; Calcium channel; Dihydropyridine; Hippocampus; Nifedipine; Purine;

D O I：

10.1016/0006-8993(90)90881-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The application of adenosine to hippocampal slices caused a suppression of evoked population spikes in the CA1 region. This effect was enhanced by nifedipine and BAYK 8644 in control slices but was reduced by these dihydropyridines in the presence of dipyridamole. Several analogues of adenosine which are not substrates for the uptake system also depressed the population spikes in the CA1 region but these responses were inhibited by nifedipine and BAYK 8644. Other dihydropyridines including nimodipine and nitrendipine did not affect sensitivity to adenosine or its analogues. It is concluded that some agonist and antagonist dihydropyridines can inhibit adenosine uptake and thus potentiate its effects but can also antagonise receptor activation. Structural features of nifedipine and BAYK 8644 may be specific for a population of dihydropyridine receptors closely linked functionally with the adenosine receptor. © 1990.

引用

页码：315 / 318

页数：4

共 35 条

[1] DIHYDROPYRIDINE RECEPTOR IN RAT-BRAIN LABELED WITH [H-3]-LABELED NIMODIPINE [J].