STEREOCHEMICAL FEATURES OF 1,4-BENZODIAZEPIN-2-ONES BOUND TO HUMAN SERUM-ALBUMIN - DIFFERENCE CD AND UV STUDIES

被引：17

作者：

BERTUCCI, C ^{[1
]}

DOMENICI, E ^{[1
]}

SALVADORI, P ^{[1
]}

机构：

[1] UNIV PISA,DIPARTIMENTO CHIM & CHIM IND,CNR,I-56126 PISA,ITALY

来源：

CHIRALITY | 1990年 / 2卷 / 03期

关键词：

benzodiazepines; chiral discrimination; circular dichroism; difference spectroscopy; electronic absorption spectra; human serum albumin; stereospecific interaction;

D O I：

10.1002/chir.530020308

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The stereochemistry of an achiral (Diazepam) and two chiral (3‐methyl and 3‐succinyloxy substituted) 1,4‐benzodiazepin‐2‐ones interacting with human serum albumin (HSA) has been investigated by making use of difference absorption (UV) and circular dichroism (CD) spectroscopies. Evidence is obtained for a higher affinity with HSA for one of the two possible conformations of the seven‐membered benzodiazepine ring. The red shift revealed by the absorption difference spectrum between the free and the bound drug accounts for the CD difference spectra observed. Copyright © 1990 Wiley‐Liss, Inc.

引用

页码：167 / 174

页数：8

共 16 条

[1] CIRCULAR-DICHROISM AND GEL-FILTRATION STUDY OF BINDING OF PROCHIRAL AND CHIRAL 1,4-BENZODIAZEPIN-2-ONES TO HUMAN-SERUM ALBUMIN [J].