MONOCYTE-MEDIATED LYSIS OF HIV-INFECTED TUMOR-CELLS

被引：1

作者：

DEBS, RJ ^{[1
]}

KROWKA, J ^{[1
]}

STITES, D ^{[1
]}

BRUNETTE, EN ^{[1
]}

DUZGUNES, N ^{[1
]}

PHILIP, R ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT LAB MED,SAN FRANCISCO,CA 94143

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1990年 / 6卷 / 08期

关键词：

D O I：

10.1089/aid.1990.6.1005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Peripheral blood monocytes (PBM) can selectively lyse malignant or virus-infected cells. We investigated the effects of target cell infection with HIV-1 on PBM cytolytic function. Cytokine-activated PBM lysed uninfected, HSV-1-infected or vaccinia virus-infected tumor cells, but did not lyse the same cell lines when infected with the human immunodeficiency virus type 1 (HIV-1). HIV did not impair PBM viability, and actinomycin D (Act D) pretreatment of HIV-infected target cells restored their susceptibility to PBM-mediated lysis. Either antibody to CD4 (Leu3a) or a recombinant vaccinia virus that induces expression of the HIV envelope protein, also inhibited target cell lysis by PBM. These studies indicate that CD4 can function as a mediator of PBM cytolytic function, and that target cell expression of the HIV-1 envelope protein may inhibit monocyte-mediated antitumor responses. © 1990, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：1005 / 1009

页数：5

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