LACK OF CROSS-TOLERANCE BETWEEN MORPHINE AND AUTOANALGESIA

被引:34
作者
CHANCE, WT [1 ]
ROSECRANS, JA [1 ]
机构
[1] MED COLL VIRGINIA,DEPT PHARMACOL,RICHMOND,VA 23298
基金
美国国家卫生研究院;
关键词
Analgesia; Autoanalgesia; Conditioned fear; Cross-tolerance; Endorphin; Morphine; Stress; Tolerance;
D O I
10.1016/0091-3057(79)90255-7
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The acquisition of autoanalgesia (behaviorally-induced antinociception) was investigated in morphine-tolerant and non-tolerant rats. Tolerance to morphine did not affect analgesia acutely-elicited by a brief (15 sec) schedule of footshock. Similarly, analgesia elicited by classically conditioned fear was not attenuated by morphine tolerance. These data suggest that endorphins may not be the principle mediators of autoanalgesic phenomena. © 1979.
引用
收藏
页码:639 / 642
页数:4
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