FELINE RETINAL ULTRASTRUCTURAL-CHANGES INDUCED BY A HIGH CYSTINE DIET

被引:1
作者
IMAKI, H
STURMAN, JA
机构
[1] Department of Developmental Biochemistry Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314
关键词
CAT RETINA; CYSTINE NEUROTOXICITY; RETINAL ULTRASTRUCTURE; TAURINE DEFICIENCY;
D O I
10.1016/S0271-5317(05)80131-9
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Cats fed a high cystine diet containing no taurine developed extreme signs of neurotoxicity and either died or had to be killed within 7 months. The presence of 0.05% taurine in the diet greatly ameliorated the neurotoxic effects of the cysine. Many developed retinal ultrastructural changes which were quite different from those proviously described for cats on taurine-free diets. The most striking changes were reductions in the number of cells and extensive swelling of some remaining cells in the inner nuclear layera and in the ganglion cell layer. The most severely affected cells were amacrine cells, in contrast to photoreceptor cells in cats fed the taurine-free diet. The changes resemble those reported in other species caused by excitotoxic amino acids.
引用
收藏
页码:1385 / 1400
页数:16
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