PHARMACOKINETIC ANALYSIS OF CORONARY SINUS RETROINFUSION IN PIGS - ISCHEMIC MYOCARDIAL CONCENTRATIONS IN THE LEFT CIRCUMFLEX CORONARY ARTERIAL AREA USING METOPROLOL AS A TRACER

被引：19

作者：

HATORI, N ^{[1
]}

SJOQUIST, PO ^{[1
]}

REGARDH, C ^{[1
]}

RYDEN, L ^{[1
]}

机构：

[1] NATL DEF MED COLL,TOKOROZAWA,SAITAMA 359,JAPAN

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1991年 / 5卷 / 06期

关键词：

CORONARY SINUS; LEFT CIRCUMFLEX CORONARY ARTERY; RETROINFUSION; METOPROLOL;

D O I：

10.1007/BF00143528

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myocardial availability of drug, using metoprolol as a tracer, in acutely ischemic myocardium in the area of the left circumflex (LCX) coronary artery was compared following standard intravenous (IV) administration and after coronary sinus retroinfusion. Seven open-chest farm pigs were subjected to a 21-minute occlusion of the LCX coronary artery. All animals received simultaneous IV tritium-labeled metoprolol (0.2 mg/kg) and unlabeled metoprolol (0.2 mg/kg) retrogradely into the coronary sinus. The drug administration was started after 1 minute of coronary artery occlusion and continued for 5 minutes. Intravenously administered metoprolol resulted in a higher peak plasma concentration of metoprolol (382 +/- 52 nmol/l) than coronary sinus retroinfusion (276 +/- 47 nmol/l). The nonischemic myocardial metoprolol concentration was of similar magnitude (393-454 pmol/g), whether infused IV or into the coronary sinus. Coronary sinus retroinfusion, however, resulted in a substantial accumulation of metoprolol in the ischemic myocardium (2887-5863 pmol/g). Coronary sinus retroinfusion resulted in a pronounced and specific accumulation in the ischemic myocardium in the territory of the LCX coronary artery.

引用

页码：1005 / 1010

页数：6

共 19 条

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