CHROMOSOME-ANOMALIES IN MOUSE ZYGOTES TREATED BY GROWTH HORMONE-RELEASING FACTOR

被引：1

作者：

ARAN, B

CALDERON, G

MORAGAS, M

TORELLO, MJ

VEIGA, A

BARRI, PN

机构：

[1] Servei de Medicina de la Reproducció, Departament d'Obstetricia i Ginecologia, Institut Universitari Dexeus, 08017 Barcelona

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 10期

关键词：

ANEUPLOIDY; CHROMOSOMAL ANOMALIES; GROWTH HORMONE-RELEASING FACTOR; MOUSE EGGS; POLYPLOIDY;

D O I：

10.1093/oxfordjournals.humrep.a137580

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The incidence of chromosome anomalies was studied in fertilized oocytes in two groups of hybrid mice in which superovulation was induced by gonadotrophins and growth hormone-releasing factor (GRF) supplementation or gonadotrophins alone (controls). The rate of fertilization was significantly higher among GRF-treated females than among controls (74.1 versus 84.7%; P < 0.013). Cytogenetic data were obtained in 262 fertilized oocytes (89 from control females and 173 from GRF-treated females). The frequency of aneuploidy, calculated as twice the frequency of hyper-haploidy was 2.31% in GRF-treated females and 2.24% in controls (NS). The use of GRF to treat female mice did not adversely affect the maturation process of oocytes nor did it induce an increased frequency of aneuploidy.

引用

页码：1394 / 1395

页数：2

共 13 条

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