ORGANIZATION OF THE MOUSE GP42/BASIGIN GENE - A MEMBER OF THE IG SUPERFAMILY

被引：14

作者：

CHENG, Y ^{[1
]}

LI, XB ^{[1
]}

KAMHOLZ, J ^{[1
]}

BURNS, FR ^{[1
]}

机构：

[1] HOSP UNIV PENN,DEPT NEUROL,PHILADELPHIA,PA 19104

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1994年 / 1217卷 / 03期

关键词：

GP42; BASIGIN; POLYMORPHIC; GENE; IMMUNOGLOBULIN SUPERFAMILY; (MOUSE);

D O I：

10.1016/0167-4781(94)90290-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have mapped and sequenced the GP42/Basigin gene isolated from a Balb/C mouse genomic library. The genomic organization and upstream, putative regulatory, regions of this gene have not been previously reported. Our data show that exon 5 of the GP42/Basigin gene encodes the carboxy proximal half of the second Ig-like domain, the highly conserved transmembrane region and a portion of the cytoplasmic tail. This inclusion of Ig-like and other functional domains in a single exon is unusual. Splice junction analysis indicates that two reported alternate GP42/Basigin cDNA isoforms are likely due to cloning artifacts. In addition, we find that GP42/Basigin is polymorphic in mice. Our data also support the proposal that the transmembrane domain and portions of the cytoplasmic region of GP42/Basigin have been evolutionarily conserved.

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页码：307 / 311

页数：5

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