COMPARISON OF THE INHIBITORY EFFECT OF THE ANGIOGENESIS INHIBITOR, TNP-470, AND MITOMYCIN-C ON THE GROWTH AND LIVER METASTASIS OF HUMAN COLON-CANCER

被引：63

作者：

KONNO, H

TANAKA, T

MATSUDA, I

KANAI, T

MARUO, Y

NISHINO, N

NAKAMURA, S

BABA, S

机构：

[1] Second Department of Surgery, Hamamatsu University School of Medicine, Hamamatsu, 431-31

来源：

INTERNATIONAL JOURNAL OF CANCER | 1995年 / 61卷 / 02期

关键词：

D O I：

10.1002/ijc.2910610221

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiogenesis inhibitors have attracted considerable interest. The anti-tumor and anti-metastatic effects of TNP-470, an angiogenesis inhibitor, and mitomycin C (MMC), a representative anti-neoplastic agent, were investigated using a xenotransplanted human colon cancer, TK-4. Suturing of small pieces of TK-4 tumors to the cecal wall in nude mice (orthotopic transplantation) induced liver metastasis. Mice were randomly divided into 3 groups; a control group given saline solution, a group receiving TNP-470 and a group receiving MMC. TNP-470 was given s.c. on alternate days for 5 weeks from day 10 after cecal transplantation and MMC was administered intraperitoneally (i.p.) once a week from day 10 after cecal transplantation. MMC significantly inhibited cecal tumor growth. In the control group, liver metastases developed in 9 out of 10 mice, including 3 with more than 20 metastatic foci. Liver metastasis also developed in 8 out of 10 mice receiving MMC, 2 of which had many metastases. In contrast, liver metastasis developed in only 2 out of 8 mice in the TNP-470 group and neither of these animals had numerous metastases. (C) 1995 Wiley-Liss, Inc.

引用

页码：268 / 271

页数：4

共 17 条

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