PANCREATIC SECRETORY TRYPSIN-INHIBITOR IN HUMAN BRUNNERS GLANDS

被引：13

作者：

BOHE, H

BOHE, M

LINDSTROM, C

OHLSSON, K

机构：

[1] Department of Surgery, University of Lund, Malmö General Hospital, Malmö

[2] Department of Pathology, University of Lund, Malmö General Hospital, Malmö

[3] Department of Surgical Pathophysiology, University of Lund, Malmö General Hospital, Malmö

来源：

JOURNAL OF GASTROENTEROLOGY | 1995年 / 30卷 / 01期

关键词：

DUODENAL GLANDS; BRUNNERS GLANDS; PANCREATIC SECRETORY TRYPSIN INHIBITOR; IMMUNOHISTOCHEMISTRY;

D O I：

10.1007/BF01211381

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Brunner's glands (duodenal glands) in humans are located mainly in the two proximal thirds of the duodenum. They are known to produce and secrete mucin. In recent years, human Brunner's glands have also been shown to express immunoreactivity toward epidermal growth factor-urogastrone (EGF-uro) and lysozyme. These proteins are considered to have a protective function within the gastrointestinal canal. Human pancreatic secretory trypsin inhibitor (PSTI) was recently identified in Brunner's glands. This present study was done by an immunohistochemical method, using monospecific polyclonal antibodies against human PSTI and human lysozyme, respectively. McManus/Alcian blue mucin staining was used to clarify the distribution of mucin. We found immunoreactive PSTI (irPSTI) in seven out of ten specimens. Lysozyme and mucin were present in all ten. While virtually all cells were stained for lysozyme and mucin, irPSTI was restricted to separate lobules and to cells in the ducts.

引用

页码：90 / 95

页数：6

共 51 条

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