KAINATE RECEPTORS - A NOVEL MECHANISM IN PARADOXICAL (REM) SLEEP GENERATION

被引：71

作者：

ONOE, H

SAKAI, K

机构：

[1] UNIV LYON 1,DEPT EXPTL MED,F-69373 LYON 08,FRANCE

[2] OSAKA BIOSCI INST,DEPT NEUROSCI,SUITA,OSAKA 565,JAPAN

[3] RES DEV CORP JAPAN,SUBFEMTOMOLE BIORECOGNIT PROJECT,OSAKA 565,JAPAN

来源：

NEUROREPORT | 1995年 / 6卷 / 02期

关键词：

EXCITATORY AMINO ACIDS; KAINATE RECEPTORS; PARADOXICAL SLEEP; PERI-LOCUS COERULEUS ALPHA;

D O I：

10.1097/00001756-199501000-00031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

APPLICATION Of kainate to the peri-locus coeruleus alpha (peri-LC alpha) resulted in a marked increase in paradoxical sleep (PS). This effect was completely blocked by specific non-NMDA receptor antagonists, but not by selective NMDA receptor antagonists. Kainate was 10 times more potent than AMPA, and their site of action was confined to the peri-LC alpha. This study is the first to show that excitatory amino acids play an important role in PS generation via the activation of kainate receptors which are located in the peri-LC alpha of the mediodorsal pontine tegmentum.

引用

页码：353 / 356

页数：4

共 26 条

[1] THE PRIMARY AFFERENT DEPOLARIZING ACTION OF KAINATE IN THE RAT [J].