ENHANCEMENT OF ANTI-SHIGELLA LIPOPOLYSACCHARIDE (LPS) RESPONSE BY ADDITION OF THE CHOLERA-TOXIN B SUBUNIT TO ORAL AND INTRANASAL PROTEOSOME SHIGELLA-FLEXNERI-2A LPS VACCINES

被引：16

作者：

ORR, N

ARNON, R

RUBIN, G

COHEN, D

BERCOVIER, H

LOWELL, GH

机构：

[1] WEIZMANN INST SCI,DEPT CHEM IMMUNOL,IL-76100 REHOVOT,ISRAEL

[2] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT CLIN MICROBIOL,IL-91010 JERUSALEM,ISRAEL

[3] WALTER REED ARMY INST RES,DIV PATHOL,WASHINGTON,DC

来源：

INFECTION AND IMMUNITY | 1994年 / 62卷 / 11期

关键词：

D O I：

10.1128/IAI.62.11.5198-5200.1994

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Addition of the cholera toxin B subunit to oral and intranasal proteosome-Shigella flexneri 2a lipopolysaccharide vaccines improved their immunogenicities. Enhancement of anti-O-Shigella immunoglobulin A levels was most evident in lung lavages following oral immunization and in lung and intestinal fluids when suboptimal doses were used with either immunization route.

引用

收藏

页码：5198 / 5200

页数：3

相关论文

共 15 条

[1]

ORAL IMMUNIZATION WITH BACTERIAL POLYSACCHARIDE AND ADJUVANT ENHANCES ANTIGEN-SPECIFIC PULMONARY SECRETORY ANTIBODY-RESPONSE AND RESISTANCE TO PNEUMONIA [J].

ABRAHAM, E ;

ROBINSON, A .

VACCINE, 1991, 9 (10) :757-764

[2]

PREVENTION OF SHIGELLOSIS BY A SALMONELLA-TYPHI-SHIGELLA SONNEI BIVALENT VACCINE [J].

BLACK, RE ;

LEVINE, MM ;

CLEMENTS, ML ;

LOSONSKY, G ;

HERRINGTON, D ;

BERMAN, S ;

FORMAL, SB .

JOURNAL OF INFECTIOUS DISEASES, 1987, 155 (06) :1260-1265

[3]

CHOLERA HOLOTOXIN AND ITS B-SUBUNIT ENHANCE PEYER PATCH B-CELL RESPONSES INDUCED BY ORALLY-ADMINISTERED INFLUENZA-VIRUS - DISPROPORTIONATE CHOLERA-TOXIN ENHANCEMENT OF THE IGA B-CELL RESPONSE [J].

CHEN, KS ;

STROBER, W .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (02) :433-436

[4]

SERUM ANTIBODIES TO LIPOPOLYSACCHARIDE AND NATURAL IMMUNITY TO SHIGELLOSIS IN AN ISRAELI MILITARY POPULATION [J].

COHEN, D ;

GREEN, MS ;

BLOCK, C ;

ROUACH, T ;

OFEK, I .

JOURNAL OF INFECTIOUS DISEASES, 1988, 157 (05) :1068-1071

[5]

IMMUNE-RESPONSE RELATED TO THE MOLECULAR-STRUCTURE OF A PEPTIDE FROM THE CHOLERA-TOXIN B-SUBUNIT [J].

HALIMI, H ;

RIVAILLE, P .

VACCINE, 1993, 11 (12) :1233-1239

[6]

COMPARISON OF INTRANASAL INOCULATION OF INFLUENZA HA VACCINE COMBINED WITH CHOLERA TOXIN-B SUBUNIT WITH ORAL OR PARENTERAL VACCINATION [J].

HIRABAYASHI, Y ;

KURATA, H ;

FUNATO, H ;

NAGAMINE, T ;

AIZAWA, C ;

TAMURA, S ;

SHIMADA, K ;

KURATA, T .

VACCINE, 1990, 8 (03) :243-248

[7]

KEUSCH GT, 1991, BACTERIAL INFECTIONS, P593

[8]

LYCKE N, 1986, IMMUNOLOGY, V59, P301

[9]

IMMUNOGENICITY AND EFFICACY OF ORAL OR INTRANASAL SHIGELLA-FLEXNERI 2A AND SHIGELLA-SONNEI PROTEOSOME-LIPOPOLYSACCHARIDE VACCINES IN ANIMAL-MODELS [J].

ORR, N ;

ROBIN, G ;

COHEN, D ;

ARNON, R ;

LOWELL, GH .

INFECTION AND IMMUNITY, 1993, 61 (06) :2390-2395

[10]

ORAL-ADMINISTRATION OF A BACTERIAL IMMUNOMODULATOR ENHANCES MURINE INTESTINAL LAMINA PROPRIA AND PEYER PATCH LYMPHOCYTE TRAFFIC TO THE LUNG - POSSIBLE IMPLICATIONS FOR INFECTIOUS-DISEASE PROPHYLAXIS AND THERAPY [J].

RUEDL, C ;

ALBIN, B ;

BOCK, G ;

WICK, G ;

WOLF, H .

INTERNATIONAL IMMUNOLOGY, 1993, 5 (01) :29-36