MEDICAL-TREATMENT OF PRIMARY PULMONARY-HYPERTENSION - A BRIDGE TO TRANSPLANTATION

被引:30
作者
RICH, S
机构
[1] Section of Cardiology, University of Illinois, Chicago College of Medicine, Chicago, IL
关键词
D O I
10.1016/S0002-9149(99)80385-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Primary pulmonary hypertension is a progressive disease with a mean survival of <3 years from the time of diagnosis. Recent advances in the medical management have shown that some patients may have an extremely good outcome depending on the response to high doses of calcium antagonists. Anticoagulants are also associated with improved survival, and prostacyclin is showing great promise in patients who are refractory to conventional therapy. At the same time, lung transplantation has developed into a viable treatment option for patients who remain symptomatic and deteriorate on medical management. The role of the various medical treatment modalities, and the ideal timing of lung transplantation, is an issue that is continuing to evolve as Improvements in all treatments develop. the cost and availability of the various treatments will likely affect the selection of treatments in individual patients as well.
引用
收藏
页码:A63 / A66
页数:4
相关论文
共 29 条
[1]   HYPOTENSION AND SINUS ARREST WITH NIFEDIPINE IN PULMONARY-HYPERTENSION [J].
AROMATORIO, GJ ;
URETSKY, BF ;
REDDY, PS .
CHEST, 1985, 87 (02) :265-267
[2]   ADVERSE HEMODYNAMIC-EFFECTS OF PHENTOLAMINE IN PRIMARY PULMONARY-HYPERTENSION [J].
COHEN, ML ;
KRONZON, I .
ANNALS OF INTERNAL MEDICINE, 1981, 95 (05) :591-592
[3]   SURVIVAL IN PATIENTS WITH PRIMARY PULMONARY-HYPERTENSION - RESULTS FROM A NATIONAL PROSPECTIVE REGISTRY [J].
DALONZO, GE ;
BARST, RJ ;
AYRES, SM ;
BERGOFSKY, EH ;
BRUNDAGE, BH ;
DETRE, KM ;
FISHMAN, AP ;
GOLDRING, RM ;
GROVES, BM ;
KERNIS, JT ;
LEVY, PS ;
PIETRA, GG ;
REID, LM ;
REEVES, JT ;
RICH, S ;
VREIM, CE ;
WILLIAMS, GW ;
WU, M .
ANNALS OF INTERNAL MEDICINE, 1991, 115 (05) :343-349
[4]   THE LOYOLA-UNIVERSITY LUNG-TRANSPLANT EXPERIENCE [J].
DOUD, JR ;
MCCABE, MM ;
MONTOYA, A ;
GARRITY, ER .
ARCHIVES OF INTERNAL MEDICINE, 1993, 153 (24) :2769-2773
[5]   FIBRINOPEPTIDE-A LEVELS INDICATIVE OF PULMONARY VASCULAR THROMBOSIS IN PATIENTS WITH PRIMARY PULMONARY-HYPERTENSION [J].
EISENBERG, PR ;
LUCORE, C ;
KAUFMAN, L ;
SOBEL, BE ;
JAFFE, AS ;
RICH, S .
CIRCULATION, 1990, 82 (03) :841-847
[6]  
FARBER HW, 1983, CHEST, V23, P708
[7]   PRIMARY PULMONARY-HYPERTENSION - NATURAL-HISTORY AND THE IMPORTANCE OF THROMBOSIS [J].
FUSTER, V ;
STEELE, PM ;
EDWARDS, WD ;
GERSH, BJ ;
MCGOON, MD ;
FRYE, RL .
CIRCULATION, 1984, 70 (04) :580-587
[8]   A DECADE OF LUNG TRANSPLANTATION [J].
GRIFFITH, BP ;
HARDESTY, RL ;
ARMITAGE, JM ;
HATTLER, BG ;
PHAM, SM ;
KEENAN, RJ ;
PARADIS, I .
ANNALS OF SURGERY, 1993, 218 (03) :310-320
[9]   TOLAZOLINE HYDROCHLORIDE (PRISCOLINE) - AN EFFECTIVE PULMONARY VASODILATOR [J].
GROVER, RF ;
REEVES, JT ;
BLOUNT, SG .
AMERICAN HEART JOURNAL, 1961, 61 (01) :5-&
[10]  
HIGENBOTTAM TW, 1993, BRIT HEART J, V70, P366