THERAPEUTIC IMPLICATIONS OF INHIBITION VERSUS KILLING OF MYCOBACTERIUM-AVIUM COMPLEX BY ANTIMICROBIAL AGENTS

被引:69
作者
YAJKO, DM
NASSOS, PS
HADLEY, WK
机构
关键词
D O I
10.1128/AAC.31.1.117
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Patients with the acquired immune deficiency syndrome (AIDS) with disseminated Mycobacterium avium infection have responded poorly to treatment with rifabutine (Ansamycin) and clofazimine, in spite of the good in vitro response of M. avium to these antimicrobial agents. We compared the ability of these and other antimicrobial agents to kill versus the ability to inhibit the growth of strains of the M. avium complex isolated from patients with AIDS. Killing curve experiments showed that the concentrations of rifabutine and clofazimine needed to kill two log units of M. avium are at least 32 times greater than the concentrations needed to inhibit growth. Like or no killing occurred at concentrations of these antimicrobial agents that are achievable in serum. In contrast, five of seven strains tested were killed by ciprofloxacin at concentrations that can be achieved in serum. Ciprofloxacin should be studied further for possible use in the treatment of M. avium infections.
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页码:117 / 120
页数:4
相关论文
共 15 条
[1]   TREATMENT OF INFECTIONS IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME [J].
ARMSTRONG, D ;
GOLD, JWM ;
DRYJANSKI, J ;
WHIMBEY, E ;
POLSKY, B ;
HAWKINS, C ;
BROWN, AE ;
BERNARD, E ;
KIEHN, TE .
ANNALS OF INTERNAL MEDICINE, 1985, 103 (05) :738-743
[2]   COMPARATIVE INVITRO ACTIVITIES OF MDL 473, RIFAMPIN, AND ANSAMYCIN AGAINST MYCOBACTERIUM-INTRACELLULARE [J].
CYNAMON, MH .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 28 (03) :440-441
[3]   PHARMACOKINETICS OF 3 ORAL FORMULATIONS OF CIPROFLOXACIN [J].
DAVIS, RL ;
KOUP, JR ;
WILLIAMSWARREN, J ;
WEBER, A ;
SMITH, AL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1985, 28 (01) :74-77
[4]   COMPARATIVE INVITRO ACTIVITIES OF CIPROFLOXACIN AND OTHER 4-QUINOLONES AGAINST MYCOBACTERIUM-TUBERCULOSIS AND MYCOBACTERIUM-INTRACELLULARE [J].
FENLON, CH ;
CYNAMON, MH .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 29 (03) :386-388
[5]   CIPROFLOXACIN CONCENTRATIONS IN BONE AND MUSCLE AFTER ORAL DOSING [J].
FONG, IW ;
LEDBETTER, WH ;
VANDENBROUCKE, AC ;
SIMBUL, M ;
RAHM, V .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 29 (03) :405-408
[6]  
GANGADHARUM PRJ, 1984, DRUG RESISTANCE MYCO, P55
[7]  
GOOD RC, 1985, ANNU REV MICROBIOL, V39, P347, DOI 10.1146/annurev.mi.39.100185.002023
[8]  
HEIFETS LB, 1985, ANTIMICROB AGENTS CH, V28, P570, DOI 10.1128/AAC.28.4.570
[9]  
Jones R., 1985, Manual of Clinical Microbiology, P972
[10]  
KUZE F, 1981, REV INFECT DIS, V3, P885