ADAPTIVE RESPONSE OF ESCHERICHIA-COLI TO LOW-LEVELS OF ALKYLATING AGENT - COMPARISON WITH PREVIOUSLY CHARACTERIZED DNA-REPAIR PATHWAYS

被引：219

作者：

JEGGO, P ^{[1
]}

DEFAIS, M ^{[1
]}

SAMSON, L ^{[1
]}

SCHENDEL, P ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND, MILL HILL LABS, LONDON NW7 1AD, ENGLAND

来源：

MOLECULAR AND GENERAL GENETICS | 1977年 / 157卷 / 01期

关键词：

D O I：

10.1007/BF00268680

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An inducible response in Escherichia coli which occurs during growth on low levels of the methylating agent, N-methyl-N''-nitro-N-nitrosoguanidine (MNNG), and which enables cells to survive better and to be less mutated by a subsequent challenge dose of MNNG than control cultures was previously described. This response is distinct from previously characterized pathways of DNA repair, and particularly from the SOS response, which is another inducible effect resulting from DNA damage. An examination of the cross-reactivity of this response with other mutagens showed that it is a generalized mechanism affecting alkylation damage to DNA. It cannot be induced by UV or the UV-mimetic mutagen, 4-nitroquinoline 1-oxide, nor act on lesions put into DNA by those mutagens.

引用

页码：1 / 9

页数：9

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