INCREASE OF INTERFERON ANTI-VIRAL ACTIVITY BY EXOGENOUS CYCLIC ADENOSINE-3'-5'-MONOPHOSPHATE (CAMP)

被引：1

作者：

KOBLET, H ^{[1
]}

WYLER, R ^{[1
]}

KOHLER, U ^{[1
]}

机构：

[1] UNIV ZURICH,INST VIROL,CH-8057 ZURICH,SWITZERLAND

来源：

EXPERIENTIA | 1979年 / 35卷 / 05期

关键词：

D O I：

10.1007/BF01960326

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Some effects of cAMP on replication of Semliki Forest Virus in chick embryo fibroblast cell cultures are described. Depending on concentration, the incorporation of [3H]-uridine into viral RNA or the formation of plaqueforming units is inhibited; the highest concentration tested was 8 mM. Cyclic AMP has an effect of its own and increases the Interferon action in the lower concentration ranges of Interferon (up to 1 unit/ml). The effect of cyclic AMP is fast, needs no induction and is also visible in late phases of viral replication. However, these experiments do not establish a causal relation between cAMP and Interferon. © 1979 Birkhäuser Verlag.

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页码：575 / 576

页数：2

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