INHIBITORY, GABAERGIC NERVE-TERMINALS DECREASE AT SITES OF FOCAL EPILEPSY

被引：289

作者：

RIBAK, CE

HARRIS, AB

VAUGHN, JE

ROBERTS, E

机构：

[1] CITY HOPE NATL MED CTR,DIV NEUROSCI,DUARTE,CA 91010

[2] UNIV WASHINGTON,DEPT NEUROL SURG,SEATTLE,WA 98195

来源：

SCIENCE | 1979年 / 205卷 / 4402期

关键词：

D O I：

10.1126/science.109922

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Using an immunocytochemical method for the localization of the γ-aminobutyric acid (GABA) synthesizing enzyme, glutamic acid decarboxylase (GAD), we have observed GABAergic nerve terminals distributed throughout all layers of normal monkey sensorimotor cortex. These terminals displayed ultrastructural characteristics that suggested that they arose from aspinous and sparsely spinous stellate neurons. In monkeys (Macaca mulatta and M. fascicularis) made epileptic by cortical application of alumina gel, a highly significant numerical decrease of GAD-positive nerve terminals occurred at sites of seizure foci indicating a functional loss of GABAergic inhibitory synapses. A loss of such inhibition at seizure foci could lead to epileptic activity of cortical pyramidal neurons. Copyright © 1979 AAAS.

引用

页码：211 / 214

页数：4

共 39 条

[1] GABAERGIC TERMINALS ARE PRESYNAPTIC TO PRIMARY AFFERENT TERMINALS IN SUBSTANTIA GELATINOSA OF RAT SPINAL-CORD [J].