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THROMBIN-STIMULATED CELL-DIVISION INVOLVES PROTEOLYSIS OF ITS CELL-SURFACE RECEPTOR

被引：77
作者：
GLENN, KC
CUNNINGHAM, DD
机构：
[1] Department of Microbiology, College of Medicine, University of California, Irvine
来源：
NATURE | 1979年 / 278卷 / 5706期
关键词：
D O I：
10.1038/278711a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A cell-surface component of molecular weight 43,000 is cleaved by thrombin on cells that divide after thrombin treatment, but is not cleaved on cells that are unresponsive to its mitogenic action. Studies with a photoreactive derivative of thrombin showed that its cell surface receptor has a molecular weight of 43,000. This indicates that thrombin must cleave its receptor to stimulate cell division. © 1979 Nature Publishing Group.
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页码：711 / 714
页数：4
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