INDUCTION OF BONE RESORBING ACTIVITY BY NORMAL AND RHEUMATOID-ARTHRITIS T-CELLS

被引：5

作者：

FLESCHER, E ^{[1
]}

GARRETT, IR ^{[1
]}

MUNDY, GR ^{[1
]}

TALAL, N ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV ENDOCRINOL,SAN ANTONIO,TX 78284

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1990年 / 56卷 / 02期

关键词：

D O I：

10.1016/0090-1229(90)90142-D

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the role of T cells in the production of osteoclast activating factor (OAF) using anti-CD3 MAb as a specific T cell activator. OAF activity was totally inhibited by anti-IL-1β. Peripheral blood mononuclear cells (PBMNC) from normal subjects produced more OAF than did PBMNC from rheumatoid arthritis (RA) patients. Mononuclear cells (MNC) from RA synovial fluid produced less OAF than did RA peripheral blood. We conclude that (i) specific T cell stimulation induces OAF production which may be attributed to interleukin 1 (IL-1) activity, (ii) the inhibition by anti-IL-1β of OAF production following anti-CD3 stimulation suggests that the T cell signal is being transmitted to the macrophage, and (iii) RA MNC are deficient in T cell-mediated OAF production. © 1990.

引用

页码：210 / 218

页数：9

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