SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW HETEROCYCLIC QUINOLINE DERIVATIVES

被引：20

作者：

AWAD, IMA

ABDELRAHMAN, AE

BAKHITE, EA

机构：

[1] Chemistry Department, Faculty of Science, Assiut university, Assiut

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1991年 / 57卷 / 3-4期

关键词：

MERCAPTOQUINOLINES; CYANOQUINOLINES; THIENOQUINOLINES; TRIAZINONES AND PYRIMIDI;

D O I：

10.1080/10426509108038862

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Alkylation of 2-mercapto-3-cyano-4-aryl-5, 6, 7, 8-tetrahydroquinoline (I) gave compounds II-IV. Cyclization of III and IV afforded thienoquinolines V and VI respectively. On diazotization of V and VI, the corresponding triazinone derivatives VII and VIII were obtained. Also, reaction of V with benzoyl chloride yielded the tetracyclic compound IX. Structures of the new compounds were established by their elemental analyses and spectral data. Some of these compounds were screened in vitro for their antibacterial activities. © 1991, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：293 / 301

页数：9