X-RAY CRYSTAL-STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L-700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY

被引:129
作者
BONE, R
VACCA, JP
ANDERSON, PS
HOLLOWAY, MK
机构
[1] MERCK SHARP & DOHME LTD,DEPT MEDICINAL CHEM,W POINT,PA 19486
[2] MERCK SHARP & DOHME LTD,DEPT MOLEC SYST,W POINT,PA 19486
关键词
D O I
10.1021/ja00024a061
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
[No abstract available]
引用
收藏
页码:9382 / 9384
页数:3
相关论文
共 28 条
[1]   STRUCTURAL INVARIANTS IN PROTEIN FOLDING [J].
CHOTHIA, C .
NATURE, 1975, 254 (5498) :304-308
[2]   ANALYTICAL MOLECULAR-SURFACE CALCULATION [J].
CONNOLLY, ML .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1983, 16 (OCT) :548-558
[3]   SOLVENT-ACCESSIBLE SURFACES OF PROTEINS AND NUCLEIC-ACIDS [J].
CONNOLLY, ML .
SCIENCE, 1983, 221 (4612) :709-713
[4]  
DARKE PL, 1989, J BIOL CHEM, V264, P2307
[5]   HIV-1 PROTEASE SPECIFICITY OF PEPTIDE CLEAVAGE IS SUFFICIENT FOR PROCESSING OF GAG AND POL POLYPROTEINS [J].
DARKE, PL ;
NUTT, RF ;
BRADY, SF ;
GARSKY, VM ;
CICCARONE, TM ;
LEU, CT ;
LUMMA, PK ;
FREIDINGER, RM ;
VEBER, DF ;
SIGAL, IS .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 156 (01) :297-303
[6]   DESIGN, ACTIVITY, AND 2.8 A CRYSTAL-STRUCTURE OF A C2 SYMMETRICAL INHIBITOR COMPLEXED TO HIV-1 PROTEASE [J].
ERICKSON, J ;
NEIDHART, DJ ;
VANDRIE, J ;
KEMPF, DJ ;
WANG, XC ;
NORBECK, DW ;
PLATTNER, JJ ;
RITTENHOUSE, JW ;
TURON, M ;
WIDEBURG, N ;
KOHLBRENNER, WE ;
SIMMER, R ;
HELFRICH, R ;
PAUL, DA ;
KNIGGE, M .
SCIENCE, 1990, 249 (4968) :527-533
[7]   EXPRESSION AND PROCESSING OF THE AIDS VIRUS REVERSE-TRANSCRIPTASE IN ESCHERICHIA-COLI [J].
FARMERIE, WG ;
LOEB, DD ;
CASAVANT, NC ;
HUTCHISON, CA ;
EDGELL, MH ;
SWANSTROM, R .
SCIENCE, 1987, 236 (4799) :305-308
[8]  
FITZGERALD PMD, 1990, J BIOL CHEM, V265, P14209
[9]   AFFINITY PURIFICATION OF THE HIV-1 PROTEASE [J].
HEIMBACH, JC ;
GARSKY, VM ;
MICHELSON, SR ;
DIXON, RAF ;
SIGAL, IS ;
DARKE, PL .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (03) :955-960
[10]  
HENDRICKSON WA, 1985, METHOD ENZYMOL, V115, P252