TUMOR-DETECTION AND LOCALIZATION USING TC-99(M)-LABELED OV-TL 3 FAB' IN PATIENTS SUSPECTED OF OVARIAN-CANCER

被引：11

作者：

TIBBEN, JG

MASSUGER, LFAG

CLAESSENS, RAMJ

SCHIJF, CPT

PAK, KY

STRIJK, SP

KENEMANS, P

CORSTENS, FHM

机构：

[1] Departments of Nuclear Medicine, University Hospital Nijmegen, Nijmegen

[2] Departments of Obstetrics and Gynaecology, University Hospital Nijmegen, Nijmegen

[3] Departments of Radiology, University Hospital Nijmegen, Nijmegen

[4] Departments of Centocor Inc, Malvern, PA

来源：

NUCLEAR MEDICINE COMMUNICATIONS | 1992年 / 13卷 / 12期

关键词：

D O I：

10.1097/00006231-199212000-00006

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Fab' fragments of the monoclonal antibody OV-TL 3, that recognizes an ovarian carcinoma-associated antigen (OA3), were labelled with Tc-99(m) using D-glucarate as a ligand. Twenty patients suspected of having primary or recurrent ovarian cancer received intravenously 1 mg of the Fab' labelled with 740 MBq Tc-99(m). Both planar and single photon emission computed tomographic (SPECT) scintigraphy were performed up to 30 h after intravenous infusion. In 19 out of 20 patients surgical and histopathological evaluation was performed between 2 and 6 days postinfusion. Imaging results were compared with X-ray computed tomography (CT), ultrasonography (US) and CA 125 serum level. Blood clearance was fast with median t1/2 beta of 9.5 h. Thirty-seven per cent of the injected dose (% ID) was excreted in the urine within the first 24 h, whereas 7% ID was excreted in the 24 h faeces. In one patient with an OA3 negative ovarian carcinoma, radioimmunoscintigraphy (RIS) did not visualize the tumour. In two other patients a benign ovarian cyst was found, also showing no elevated uptake. In 13 out of 17 patients ovarian cancer lesions were detected with RIS, whereas CT and US detected lesions in, respectively, 15 and 12 patients. Of 36 surgically defined tumour deposits larger than 1 cm in diameter, 53% were detected and localized with RIS, whereas CT and US detected 61 and 40%, respectively. Radioimmunoscintigraphy with Tc-99(m)-OV-TL 3 Fab' is less distressing for the patients but the overall imaging performance is not improved when compared with In-111-OV-TL 3 F(ab')2.

引用

页码：885 / 893

页数：9

共 26 条

[1]

Massuger L., Kenemans P., Claessens R., Et al., Immunoscintigraphy of ovarian cancer with indium-111- labelled OV-TL 3 F(Ab')2 monoclonal antibody, J Nucl Med, 31, pp. 1802-1810, (1990)

[2]

Massuger L., Thomas C., Segers M., Et al., In-Labelled OV-TL 3-F(Ab')2 Fragments

[3]

Halpern S.E., Dillman R.O., Problems associated with radioimmunodetection and possibilities for future solutions, J Biol Resp Modif, 6, pp. 235-262, (1987)

[4]

Eckelman W.C., Development of radiochemically pure antibodies, Cancer Res, 50, pp. 780-782, (1990)

[5]

Schwarz A., Steinstrasser A., A novel approach to Tc-99m- labelled monoclonal antibodies, J Nucl Med, 28, (1987)

[6]

Eckleman W.C., Paik C.H., Steigman J., Three approaches to radiolabelling with 99Tcm, Nucl Med Biol, 16, pp. 171-176, (1989)

[7]

Hnatowich D.J., Antibody radiolabelling, problems and promises, Nucl Med Biol, 17, pp. 49-55, (1990)

[8]

Steigman J., Williams H.P., Solomon N.A., The importance of the protein sulphydryl group in HSA labelling with 99Tcm, J Nucl Med, 16, (1975)

[9]

Paik C.H., Pham L., Hong J.J., Et al., The labelling of high affinity sites of antibodies with 99Tcm, Int. J Nucl Med Biol, 12, pp. 3-8, (1985)

[10]

Pak K., Nedelman M.A., Stewart R., A rapid and efficient method for labelling antibodies with Tc-99m and comparison to the Tc-99m Fab' antibody fragments, J Nucl Med, 793, (1989)

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