GLUTAMATE ACCUMULATION AND INCREASED HYDROXYL FREE-RADICAL FORMATION IN THE ABDOMINAL-AORTA AND HEART OF GERBIL AFTER ISCHEMIA REPERFUSION INSULT

被引：17

作者：

DELBARRE, B ^{[1
]}

FLOYD, RA ^{[1
]}

DELBARRE, G ^{[1
]}

CALINON, F ^{[1
]}

机构：

[1] OKLAHOMA MED RES FDN,MOLEC TOXICOL RES PROGRAM,OKLAHOMA CITY,OK 73104

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1992年 / 13卷 / 01期

关键词：

GLUTAMATE; OXYGEN FREE RADICALS; ISCHEMIA REPERFUSION; GERBIL AORTA AND HEART; FREE RADICALS;

D O I：

10.1016/0891-5849(92)90162-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The concentration of glutamate as well as the hydroxylation of salicylate, as an index of hydroxyl free radical formation, has been determined in the abdominal aorta and heart of gerbils undergoing an ischemia/reperfusion insult (IRI) and compared to control sham-operated gerbils. The amount of glutamate and hydroxylated salicylate (dihydroxybenzoic acid, DHBA) was significantly increased in both the aorta and heart of IRI-treated gerbils as compared to the aorta and in the heart of sham-operated gerbils. Vitamin E (90 mg/kg at 24 and 1 h prior to an IRI) pretreatment prevented the increase of both glutamate and DHBA in both the aorta and heart of IRI-lesioned gerbils. The results suggest that increases in glutamate, perhaps due to the decreased activities of glutamine synthetase, are correlated with increased oxygen free radical formation during an ischemia/reperfusion insult to the heart.

引用

页码：31 / 34

页数：4

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