EFFECT OF PHENCYCLIDINE ON ENDOGENEOUS EXCITATORY AMINO-ACID RELEASE FROM THE RAT ANTERIOR CINGULATE CORTEX - AN IN-VIVO MICRODIALYSIS STUDY

被引：10

作者：

YONEZAWA, Y ^{[1
]}

HONDO, H ^{[1
]}

HASHIMOTO, K ^{[1
]}

MATSUMOTO, T ^{[1
]}

HIRANO, M ^{[1
]}

UCHIMURA, H ^{[1
]}

KUROKI, T ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC MED,DEPT NEUROPSYCHIAT,FUKUOKA,JAPAN

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1993年 / 94卷 / 03期

关键词：

PHENCYCLIDINE; ASPARTATE; GLUTAMATE; N-METHYL-D-ASPARTATE RECEPTOR; ANTERIOR CINGULATE CORTEX; MICRODIALYSIS;

D O I：

10.1007/BF01277028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of systemically administered phencyclidine (PCP) on the extracellular concentration of aspartate (Asp) and glutamate (Glu) in the rat anterior cingulate cortex was investigated using in vivo microdialysis. PCP significantly reduced the K+-evoked release of Asp and Glu, while it had no effect on the basal efflux of Asp and Glu. These results suggest that PCP might inhibit excitatory amino acid (EAA) release through an N-methyl-D-aspartate (NMDA) receptor-mediated mechanism.

引用

收藏

页码：235 / 240

页数：6

相关论文

共 23 条

[1] CURRENT VIEWS OF THE PATHOBIOCHEMISTRY OF EPILEPSY [J].

BRADFORD, HF ;

PETERSON, DW .

MOLECULAR ASPECTS OF MEDICINE, 1987, 9 (02) :119-172

[2] REGULATION OF EXCITATORY AMINO-ACID RELEASE BY N-METHYL-D-ASPARTATE RECEPTORS IN RAT STRIATUM - INVIVO MICRODIALYSIS STUDIES [J].

BUSTOS, G ;

ABARCA, J ;

FORRAY, MI ;

GYSLING, K ;

BRADBERRY, CW ;

ROTH, RH .

BRAIN RESEARCH, 1992, 585 (1-2) :105-115

[3] EXCITATORY AMINO-ACID ANTAGONISTS AND ENDOGENOUS ASPARTATE AND GLUTAMATE RELEASE FROM RAT HIPPOCAMPAL SLICES [J].

CONNICK, JH ;

STONE, TW .

BRITISH JOURNAL OF PHARMACOLOGY, 1988, 93 (04) :863-867

[4] ANATOMICAL ORGANIZATION OF EXCITATORY AMINO-ACID RECEPTORS AND THEIR PATHWAYS [J].

COTMAN, CW ;

MONAGHAN, DT ;

OTTERSEN, OP ;

STORMMATHISEN, J .

TRENDS IN NEUROSCIENCES, 1987, 10 (07) :273-280

[5] MESOLIMBIC AND MESOCORTICAL DOPAMINE ACTIVATION INDUCED BY PHENCYCLIDINE - CONTRASTING PATTERN TO STRIATAL RESPONSE [J].

DEUTCH, AY ;

TAM, SY ;

FREEMAN, AS ;

BOWERS, MB ;

ROTH, RH .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 134 (03) :257-264

[6] A GLUTAMATERGIC HYPOTHESIS OF SCHIZOPHRENIA - RATIONALE FOR PHARMACOTHERAPY WITH GLYCINE [J].

DEUTSCH, SI ;

MASTROPAOLO, J ;

SCHWARTZ, BL ;

ROSSE, RB ;

MORIHISA, JM .

CLINICAL NEUROPHARMACOLOGY, 1989, 12 (01) :1-13

[7] EXCITATORY AMINO-ACID SYNAPTIC MECHANISMS AND NEUROLOGICAL FUNCTION [J].

FAGG, GE ;

FOSTER, AC ;

GANONG, AH .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1986, 7 (09) :357-363

[8] GLUTAMATE - A NEUROTRANSMITTER IN MAMMALIAN BRAIN [J].

FONNUM, F .

JOURNAL OF NEUROCHEMISTRY, 1984, 42 (01) :1-11

[9]

JAVITT DC, 1991, AM J PSYCHIAT, V148, P1301

[10] INHIBITION BY PHENCYCLIDINE OF EXCITATORY AMINO ACID-STIMULATED RELEASE OF NEUROTRANSMITTER IN THE NUCLEUS-ACCUMBENS [J].

JONES, SM ;

SNELL, LD ;

JOHNSON, KM .

NEUROPHARMACOLOGY, 1987, 26 (2-3) :173-179