CHLOROQUINE-RESISTANT PLASMODIUM-FALCIPARUM ISOLATES FROM THE SUDAN LACK 2 MUTATIONS IN THE PFMDR1 GENE THOUGHT TO BE ASSOCIATED WITH CHLOROQUINE RESISTANCE

被引：63

作者：

AWADELKARIEM, FM

MILES, MA

WARHURST, DC

机构：

[1] Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, Keppel Street

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1992年 / 86卷 / 06期

关键词：

D O I：

10.1016/0035-9203(92)90140-8

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Isolates of Plasmodium falciparum from 3 areas of the Sudan were recovered from cryopreservation in London and their chloroquine sensitivity was determined in vitro. Chloroquine resistance was detected in 6/6 isolates from Khartoum, 1/4 from Sennar and 3/3 from Gadarif, indicating that resistance is spreading. All the isolates were sensitive to mefloquine. Studies using blood spots on glass fibre discs and the polymerase chain reaction did not detect two mutations in the pfmdr1 gene, thought to be correlated with chloroquine-resistance, in any of the isolates studied.

引用

页码：587 / 589

页数：3

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