LIFE SURVIVAL AND CARDIOVASCULAR STRUCTURES FOLLOWING SELECTIVE BETA-BLOCKADE IN SPONTANEOUSLY HYPERTENSIVE RATS

被引：17

作者：

BENETOS, A ^{[1
]}

POITEVIN, P ^{[1
]}

PROST, PL ^{[1
]}

SAFAR, ME ^{[1
]}

LEVY, BI ^{[1
]}

机构：

[1] HOP LARIBOISIERE,INSERM,U141,F-75010 PARIS,FRANCE

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1994年 / 7卷 / 02期

关键词：

SPONTANEOUSLY HYPERTENSIVE RATS; SELECTIVE BETA-BLOCKING AGENTS; ARTERIAL AND CARDIAC STRUCTURE;

D O I：

10.1093/ajh/7.2.186

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The aim of this study was to assess life survival, and arterial and cardiac structural changes following chronic selective beta-blockade in spontaneously hypertensive rats (SHR). Twenty-two SHR aged 3 months and 20 SHR aged 18 months were treated with the beta(1)-blocking agent bisoprolol (10 mg/kg/ day) or placebo for a period of 2 months. At the end of this period left and right ventricular weight and morphometric parameters of five different arterial segments (thoracic and abdominal aorta, renal, mesenteric, and carotid arteries) were evaluated. In younger SHR, systolic blood pressure (tail-cuff method) was significantly lower in drug-treated animals (225 +/- 15 v 185 +/- 10 mm Hg in placebo-treated animals; P < .001); left ventricular weight was significantly lower in drug-treated rats (0.845 +/- 0.02 v 0.932 +/- 0.03 g; P < .05); medial thickness was significantly lower in the bisoprolol-treated rats at the site of the thoracic (-22%) and abdominal (-17%) aorta, and mesenteric artery (-29%); in the renal and carotid arteries, no change in medial thickness was observed. In older SHR, cardiovascular morbidity and mortality were significantly higher (P < .01) in the placebo group. In bisoprolol-treated animals, systolic blood pressure did not change and was even significantly higher than in controls. Heart weight and medial thickness of the thoracic aorta and the renal arteries were significantly lower in the Bisoprolol group. These results provide evidence that 2 months of selective beta-blockade in adult SHR has an important antihypertrophic cardiac and vascular effect. The differences observed among the studied arterial segments cannot be due to blood pressure changes and may be related to intrinsic structural particularities or different influences of the adrenergic tone. In older animals, the structural changes were associated with a significant improvement of life survival, together with decrease in the development of heart failure.

引用

页码：186 / 192

页数：7

共 30 条

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