ESTIMATION OF DOUBLE-STRAND BREAK QUALITY BASED ON TRACK-STRUCTURE CALCULATIONS

被引：17

作者：

MICHALIK, V

机构：

[1] Institute of Radiation, Dosimetry, Prague 8, 18086

来源：

RADIATION AND ENVIRONMENTAL BIOPHYSICS | 1993年 / 32卷 / 03期

关键词：

D O I：

10.1007/BF01209774

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of this study was to investigate whether double-strand break (DSB) quality is related to the complexity of radiation-induced damage or to the spatial distribution of initial DSBs. The analysis was based on track structure calculations and DNA damage modelling. The results obtained indicate that the quality of DSBs is related to their initial spatial distribution rather than to their complexity.

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页码：251 / 258

页数：8

相关论文

共 17 条

[1]

BARENDSEN GW, 1990, RADIAT PROT DOSIM, V31, P235

[2]

BELLI M, 1992, BIOPHYSICAL MODELLING OF RADIATION EFFECTS, P285

[3] DNA DOUBLE-STRAND BREAK REPAIR DETERMINES THE RBE OF ALPHA-PARTICLES [J].

BLOCHER, D .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1988, 54 (05) :761-771

[4] CONSTRAINTS ON ENERGY DEPOSITION AND TARGET SIZE OF MULTIPLY DAMAGED SITES ASSOCIATED WITH DNA DOUBLE-STRAND BREAKS [J].

BRENNER, DJ ;

WARD, JF .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1992, 61 (06) :737-748

[5] LETHAL AND POTENTIALLY LETHAL LESIONS INDUCED BY RADIATION - A UNIFIED REPAIR MODEL [J].

CURTIS, SB .

RADIATION RESEARCH, 1986, 106 (02) :252-270

[6] EVIDENCE FOR DNA DOUBLE-STRAND BREAKS AS THE CRITICAL LESIONS IN YEAST-CELLS IRRADIATED WITH SPARSELY OR DENSELY IONIZING-RADIATION UNDER OXIC OR ANOXIC CONDITIONS [J].

FRANKENBERG, D ;

FRANKENBERGSCHWAGER, M ;

BLOCHER, D ;

HARBICH, R .

RADIATION RESEARCH, 1981, 88 (03) :524-532

[7] EFFECTIVENESS OF 1.5KEV ALUMINUM-K AND 0.3KEV CARBON-K CHARACTERISTIC X-RAYS AT INDUCING DNA DOUBLE-STRAND BREAKS IN YEAST-CELLS [J].

FRANKENBERG, D ;

GOODHEAD, DT ;

FRANKENBERGSCHWAGER, M ;

HARBICH, R ;

BANCE, DA ;

WILKINSON, RE .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1986, 50 (04) :727-741

[8] INDUCTION, REPAIR AND BIOLOGICAL RELEVANCE OF RADIATION-INDUCED DNA LESIONS IN EUKARYOTIC CELLS [J].

FRANKENBERGSCHWAGER, M .

RADIATION AND ENVIRONMENTAL BIOPHYSICS, 1990, 29 (04) :273-292

[9] A COMPARATIVE-STUDY OF REJOINING OF DNA DOUBLE-STRAND BREAKS IN YEAST IRRADIATED WITH 3.5 MEV ALPHA-PARTICLES OR WITH 30 MEV ELECTRONS [J].

FRANKENBERGSCHWAGER, M ;

FRANKENBERG, D ;

HARBICH, R ;

ADAMCZYK, C .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1990, 57 (06) :1151-1168

[10] THE INITIAL PHYSICAL DAMAGE PRODUCED BY IONIZING-RADIATIONS [J].

GOODHEAD, DT .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1989, 56 (05) :623-634