AN INTER-COMPANY CROSS-VALIDATION EXERCISE ON CAPILLARY ELECTROPHORESIS TESTING OF DOSE UNIFORMITY OF PARACETAMOL CONTENT IN FORMULATIONS

被引：56

作者：

ALTRIA, KD

CLAYTON, NG

HART, M

HARDEN, RC

HEVIZI, J

MAKWANA, JV

PORTSMOUTH, MJ

机构：

[1] PFIZER LTD,CENT RES,SANDWICH CT13 9NJ,KENT,ENGLAND

[2] RHONE POULENC RORER LTD,DAGENHAM,ENGLAND

[3] LILLY RES CTR LTD,WINDLESHAM GU20 6PH,SURREY,ENGLAND

[4] SMITHKLINE BEECHAM PHARMACEUT LTD,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

[5] BOOTS CO,NOTTINGHAM,ENGLAND

[6] FISONS PHARMACEUT,LOUGHBOROUGH,ENGLAND

来源：

CHROMATOGRAPHIA | 1994年 / 39卷 / 3-4期

关键词：

CAPILLARY ELECTROPHORESIS; MECC; DRUG ANALYSIS; PARACETAMOL;

D O I：

10.1007/BF02274498

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Successful transfer of an MECC method for the determination of paracetamol between 7 companies is shown. The method was applied to the quantitative determination of paracetamol levels in capsules. The results obtained agreed well between companies and with both HPLC data and the label claim. Acceptable method performance in terms of relative migration time precision and response factor precision was reported by each company.

引用

页码：180 / 184

页数：5

共 11 条

[1] COMPARISON OF ISOTACHOPHORESIS, CAPILLARY ZONE ELECTROPHORESIS AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THE DETERMINATION OF SALBUTAMOL, TERBUTALINE SULFATE AND FENOTEROL HYDROBROMIDE IN PHARMACEUTICAL DOSAGE FORMS
ACKERMANS, MT
BECKERS, JL
EVERAERTS, FM
SEELEN, IGJA
[J]. JOURNAL OF CHROMATOGRAPHY, 1992, 590 (02): : 341 - 353
[2] INTER-COMPANY CROSS-VALIDATION EXERCISE ON CAPILLARY ELECTROPHORESIS .1. CHIRAL ANALYSIS OF CLENBUTEROL
ALTRIA, KD
HARDEN, RC
HART, M
HEVIZI, J
HAILEY, PA
MAKWANA, JV
PORTSMOUTH, MJ
[J]. JOURNAL OF CHROMATOGRAPHY, 1993, 641 (01): : 147 - 153
[3] ALTRIA KD, 1991, J LIQ CHROMATOGR, V16, P2281
[4] SEPARATION AND SIMULTANEOUS DETERMINATION OF THE ACTIVE INGREDIENTS IN THEOPHYLLINE TABLETS BY MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY
DANG, QX
YAN, LX
SUN, ZP
LING, DK
[J]. JOURNAL OF CHROMATOGRAPHY, 1993, 630 (1-2): : 363 - 369
[5] PH HYSTERESIS EFFECT WITH SILICA CAPILLARIES IN CAPILLARY ZONE ELECTROPHORESIS
LAMBERT, WJ
MIDDLETON, DL
[J]. ANALYTICAL CHEMISTRY, 1990, 62 (15) : 1585 - 1587
[6] MAKWANA JV, COMMUNICATION
[7] PHARMACEUTICAL DRUG SEPARATIONS BY HPCE - PRACTICAL GUIDELINES
MCLAUGHLIN, GM
NOLAN, JA
LINDAHL, JL
PALMIERI, RH
ANDERSON, KW
MORRIS, SC
MORRISON, JA
BRONZERT, TJ
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1992, 15 (6-7): : 961 - 1021
[8] Moring S. E., 1990, LC GC International, V3, P46
[9] APPLICATION OF MICELLAR ELECTROKINETIC CHROMATOGRAPHY TO PHARMACEUTICAL ANALYSIS
NISHI, H
TERABE, S
[J]. ELECTROPHORESIS, 1990, 11 (09) : 691 - 701
[10] METHOD DEVELOPMENT AND SELECTIVITY CONTROL FOR SMALL MOLECULE PHARMACEUTICAL SEPARATIONS BY CAPILLARY ELECTROPHORESIS
SWARTZ, ME
[J]. JOURNAL OF LIQUID CHROMATOGRAPHY, 1991, 14 (05): : 923 - 938

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