PARTIAL NUCLEOTIDE AND AMINO-ACID-SEQUENCES OF THE ENVELOPE AND THE ENVELOPE NONSTRUCTURAL PROTEIN-1 GENE JUNCTION OF 4 DENGUE-2 VIRUS-STRAINS ISOLATED DURING THE 1981 CUBAN EPIDEMIC

被引：59

作者：

GUZMAN, MG ^{[1
]}

DEUBEL, V ^{[1
]}

PELEGRINO, JL ^{[1
]}

ROSARIO, D ^{[1
]}

MARRERO, M ^{[1
]}

SARIOL, C ^{[1
]}

KOURI, G ^{[1
]}

机构：

[1] INST PASTEUR, DEPT VIROL, PARIS, FRANCE

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1995年 / 52卷 / 03期

关键词：

D O I：

10.4269/ajtmh.1995.52.241

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In 1981, an epidemic of dengue hemorrhagic fever (DHF) caused by dengue-2 virus occurred in Cuba. This was the first DHF epidemic reported in the Western Hemisphere. In this study, we have analyzed four dengue-2 Cuban strains for two short genomic fragments: one on the envelope (E) glycoprotein and one at the E/nonstructural protein-1 (NS1) gene junction. The E segment of these 1981 Cuban isolates were more closely related to older dengue-2 virus strains such as New Guinea C 1944, Thailand 1964, Sri Lanka 1968, and Burma 1976 than to more recent isolates of this virus from Jamaica and Vietnam. More than 9% of the divergence with strains isolated from Jamaica and Vietnam was observed at the E/NS1 gene junction. One nucleotide change was observed between the first strain isolated during the epidemic and the rest of the Cuban strains. This mutation induced a nonconserved amino acid change from phenylalanine to leucine at position 43 that was not observed in any of the other strains with which it was compared.

引用

页码：241 / 246

页数：6

共 26 条

[1] NS-1 GENE-SEQUENCES FROM 8 DENGUE-2 VIRUSES AND THEIR EVOLUTIONARY RELATIONSHIPS WITH OTHER DENGUE-2 VIRUSES [J].