STUDIES ON THE REACTION-PRODUCTS OF ANTITUMOR PLATINUM COMPLEX WITH D(APG), D(GPA), AND D(PGPA) - 2'-DEOXY SUGAR IS FAVORABLE FOR G-N7, A-N1 CHELATION

被引：9

作者：

INAGAKI, K

TOMITA, A

KIDANI, Y

机构：

[1] Nagoya City Univ, Nagoya, Jpn, Nagoya City Univ, Nagoya, Jpn

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1988年 / 61卷 / 08期

关键词：

BIOCHEMISTRY - BIOLOGICAL MATERIALS - DNA - CHEMICAL REACTIONS - Reaction Kinetics - CHROMATOGRAPHIC ANALYSIS - High Performance Liquid - PLATINUM COMPOUNDS;

D O I：

10.1246/bcsj.61.2825

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction products of dichloro(1R,2R)-1,2-cyclohexanediamine)platinum(II), Pt(R,R-dach)Cl//2, with dinucleotides, d(ApG), d(GpA), and d(pGpA) have been separated by HPLC, and each product fractionated has been characterized by UV and CD spectral analyses. A competition reaction between d(ApG) and d(GpA) for Pt(R,R-dach)Cl//2 indicates that d(ApG) was about 2 times more reactive than d(GpA). The reactivity decreases along the series; d(pGpA) greater than d(ApG) greater than d(GpA).

引用

页码：2825 / 2831

页数：7

共 37 条

[1] INTRASTRAND BIS(GUANINE) CHELATION OF D(CPGPG) TO CISPLATINUM - AN X-RAY SINGLE-CRYSTAL STRUCTURE-ANALYSIS
ADMIRAAL, G
VANDERVEER, JL
DEGRAAFF, RAG
DENHARTOG, JHJ
REEDIJK, J
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (02) : 592 - 594
[2] INVIVO EFFECTS OF CIS-DIAMMINEDICHLOROPLATINUM(II) AND TRANS-DIAMMINEDICHLOROPLATINUM(II) ON SV40 CHROMOSOMES - DIFFERENTIAL REPAIR, DNA PROTEIN CROSS-LINKING, AND INHIBITION OF REPLICATION
CICCARELLI, RB
SOLOMON, MJ
VARSHAVSKY, A
LIPPARD, SJ
[J]. BIOCHEMISTRY, 1985, 24 (26) : 7533 - 7540
[3] CONFORMATIONAL-ANALYSIS OF THE ADDUCT CIS-[PT(NH3)2(D(GPG))]+ IN AQUEOUS-SOLUTION - A HIGH-FIELD (500-300 MHZ) NUCLEAR MAGNETIC-RESONANCE INVESTIGATION
DENHARTOG, JHJ
ALTONA, C
CHOTTARD, JC
GIRAULT, JP
LALLEMAND, JY
DELEEUW, FAAM
MARCELIS, ATM
REEDIJK, J
[J]. NUCLEIC ACIDS RESEARCH, 1982, 10 (15) : 4715 - 4730
[4] COORDINATION OF 9-METHYLADENINE TO [CIS-PT(NH3)2]2+ AND [PT(DIEN)]2+ AS STUDIED BY PROTON NMR
DENHARTOG, JHJ
VANDENELST, H
REEDIJK, J
[J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 1984, 21 (01) : 83 - 92
[5] KINETIC-STUDIES ON THE DIAQUA FORM OF CISPLATIN AND VARIOUS NUCLEOBASES
EAPEN, S
GREEN, M
ISMAIL, IM
[J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 1985, 24 (03) : 233 - 237
[6] INTERSTRAND CROSS-LINKS AND SEQUENCE SPECIFICITY IN THE REACTION OF CIS-DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) WITH DNA
EASTMAN, A
[J]. BIOCHEMISTRY, 1985, 24 (19) : 5027 - 5032
[7] CHARACTERIZATION OF THE ADDUCTS PRODUCED IN DNA BY CIS-DIAMMINEDICHLOROPLATINUM(II) AND CIS-DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
EASTMAN, A
[J]. BIOCHEMISTRY, 1983, 22 (16) : 3927 - 3933
[8] DETECTION AND QUANTIFICATION OF ADDUCTS FORMED UPON INTERACTION OF DIAMMINEDICHLOROPLATINUM (II) WITH DNA, BY ANION-EXCHANGE CHROMATOGRAPHY AFTER ENZYMATIC DEGRADATION
FICHTINGERSCHEPMAN, AMJ
LOHMAN, PHM
REEDIJK, J
[J]. NUCLEIC ACIDS RESEARCH, 1982, 10 (17) : 5345 - 5356
[9] ADDUCTS OF THE ANTITUMOR DRUG CIS-DIAMMINEDICHLOROPLATINUM(II) WITH DNA - FORMATION, IDENTIFICATION, AND QUANTITATION
FICHTINGERSCHEPMAN, AMJ
VANDERVEER, JL
DENHARTOG, JHJ
LOHMAN, PHM
REEDIJK, J
[J]. BIOCHEMISTRY, 1985, 24 (03) : 707 - 713
[10] MONOFUNCTIONAL AND BIFUNCTIONAL BINDING OF CIS-DIAMMINEDICHLOROPLATINUM(II) TO DINUCLEOTIDES
FORSTI, A
LAATIKAINEN, R
HEMMINKI, K
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1987, 63 (01) : 1 - 14

← 1 2 3 4 →