SYNOVIAL PERMEABILITY IN RHEUMATOID-ARTHRITIS

被引：92

作者：

SIMKIN, PA

PIZZORNO, JE

机构：

[1] University of Washington, Department of Medicine, Division of Rheumatology, Seattle, Washington

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 07期

关键词：

D O I：

10.1002/art.1780220701

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In patients with rheumatoid arthritis, as well as in persons with other kinds of synovitis, proteins enter the knee joint more rapidly than in normal individuals (P < 0.001). The rheumatoid synovium, however, is less permeable to small molecules (tritiated water, P < 0.02; urate, P < 0.05; and glucose, P < 0.002) than is the normal joint lining. This difference is explained if rheumatoid microvascular changes enhance synovial permeability to proteins while coexisting interstitial changes diminish synovial permeability to smaller molecules. Copyright © 1979 American College of Rheumatology

引用

页码：689 / 696

页数：8

共 27 条

[1]

Bennett P.H., 1967, B RHEUM DIS, V17, P453

[2]

BITTNER DL, 1966, AUTOMATION ANALYTICA, V1, P33

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