GENERATION OF INTERLEUKIN-8 BY PLASMIN FROM AVLPR-INTERLEUKIN-8, THE HUMAN FIBROBLAST-DERIVED NEUTROPHIL CHEMOTACTIC FACTOR

被引：54

作者：

NAKAGAWA, H

HATAKEYAMA, S

IKESUE, A

MIYAI, H

机构：

[1] Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, 930-01, Sugitani

来源：

FEBS LETTERS | 1991年 / 282卷 / 02期

关键词：

INTERLEUKIN-8; FIBROBLAST; PLASMIN; NEUTROPHIL CHEMOTACTIC FACTOR;

D O I：

10.1016/0014-5793(91)80526-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.

引用

页码：412 / 414

页数：3

共 16 条

[1] NEUTROPHIL-ACTIVATING PEPTIDE-1 INTERLEUKIN-8, A NOVEL CYTOKINE THAT ACTIVATES NEUTROPHILS [J].