ASYMMETRIC MICHAEL ADDITION OF THE N-ALKYLIDENE DERIVATIVE OF AN ALPHA-AMINO ESTER TO METHYL (E)-3-((3R,7AS)-2-PHENYLPERHYDROPYRROLO(1,2-C)IMIDAZOL-3-YL)PROPENOATE

被引：16

作者：

YAMAMOTO, H

KANEMASA, S

WADA, E

机构：

[1] KYUSHU UNIV, INST ADV MAT STUDY, FUKUOKA 812, JAPAN

[2] KYUSHU UNIV, INTERDISCIPLINARY GRAD SCH ENGN SCI, DEPT MOLEC SCI & TECHNOL, KASUGA, FUKUOKA 816, JAPAN

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1991年 / 64卷 / 09期

关键词：

D O I：

10.1246/bcsj.64.2739

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The exclusively diastereoselective asymmetric Michael addition of the lithiated methyl N-(2,2-dimethylpropylidene)glycinate to methyl (E)-3-[(3R,7aS)-2-phenylperhydropyrrolo[1,2-c]imidazol-3-yl]propenoate is described. The synperiplanar conformer of the acceptor propenoate participated in the reaction where the re-face of the acceptor molecule was attacked by the re(beta)-face of the lithiated intermediate.

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页码：2739 / 2743

页数：5

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