SYNTHESIS OF DIASTEREOMERIC KETOCONAZOLE ANALOGS .1.

被引：15

作者：

CHAPMAN, DR

BAUER, L

WALLER, DP

ZANEVELD, LJD

机构：

[1] UNIV ILLINOIS, DEPT PHARMACOKINET, CHICAGO, IL 60680 USA

[2] RUSH UNIV, COLL MED, DEPT OBSTET PHYSIOL & BIOCHEM, CHICAGO, IL 60612 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 07期

关键词：

D O I：

10.1002/jhet.5570270739

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of trans-isomers of ketoconazole, and the corresponding des-acetyl, 1-methyl-, 1-formyl and 1-methanesulfonyl analogs were investigated. These isomers, along with the corresponding cis-diastereomers were characterized by their carbon-13 nmr spectra.

引用

页码：2063 / 2068

页数：6

共 13 条

[1]

BOSSCHE HV, 1988, STEROL BIOSYNTHESIS, P91

[2]

BREWSTER K, 1972, CHIM INDUSTR-MILAN, V7, P87

[3] SYNTHESIS AND C-13 NMR-SPECTRA OF CIS-(2-(HALOARYL)2-[(1H-IMIDAZOL)-1-YL]METHYL])-1,3-DIOXOLANE-4-METHANOLS AND TRANS-(2-(HALOARYL)2-[(1H-IMIDAZOL)-1-YL]METHYL])-1,3-DIOXOLANE-4-METHANOLS .1. [J].