SLEEP, AGE, DEPRESSION AND THE CHOLINERGIC REM INDUCTION TEST WITH RS-86

被引：20

作者：

RIEMANN, D ^{[1
]}

BERGER, M ^{[1
]}

机构：

[1] UNIV FREIBURG,PSYCHIAT CLIN,W-7800 FREIBURG,GERMANY

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 1992年 / 16卷 / 03期

关键词：

CHOLINERGIC SYSTEM; MAJOR DEPRESSION; REM LATENCY; RS-86;

D O I：

10.1016/0278-5846(92)90082-P

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

1. Healthy volunteers and patients with a major depressive disorders were administered 1.5 mg RS 86 (a cholinergic agonist) and placebo in a randomized double-blind cross-over design at 10 p.m. prior to bedtime. 2. Polysomnographic recordings demonstrated a significantly more pronounced shortening of REM latency after cholinergic stimulation in depressed patients compared to healthy subjects. 3. Even those depressed patients displaying placebo REM latencies in the normal range showed sleep onset REM periods after cholinergic stimulation. 4. The results support the reciprocal interaction model of NonREM-REM sleep regulation and the cholinergic-aminergic imbalance model of depression.

引用

页码：311 / 316

页数：6

共 16 条

[1]

BERGER M, 1989, ARCH GEN PSYCHIAT, V46, P421

[2] EVOLVING CONCEPTS OF SLEEP CYCLE GENERATION - FROM BRAIN CENTERS TO NEURONAL POPULATIONS [J].