HMG-COA REDUCTASE INHIBITOR USE IN THE AGED - A REVIEW OF CLINICAL-EXPERIENCE

被引:8
作者
LINTOTT, CJ
SCOTT, RS
机构
[1] Lipid and Diabetes Research Group, Christchurch Hospital, Hagley, 2nd Floor
关键词
D O I
10.2165/00002512-199202060-00007
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
While the benefit of cholesterol-lowering in the elderly has yet to be proven in clinical trials, individuals at high risk of coronary events who otherwise enjoy a good quality of life, should not be denied cholesterol-lowering therapy on the basis of age alone. Moreover, hypolipidaemic drugs are already extensively used in the aged. The HMG-CoA reductase inhibitors lovastatin, simvastatin and pravastatin are potent well tolerated hypolipidaemic therapies in young subjects. Although there have been few studies on their use in elderly subjects, the available data suggest the efficacy and safety of HMG-CoA reductase inhibitors is similar to that established for younger age groups.
引用
收藏
页码:518 / 529
页数:12
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