STABILIZATION OF INDUCIBLE NITRIC-OXIDE SYNTHASE BY MONOCLONAL-ANTIBODIES

被引：13

作者：

HATTORI, R

KOSUGA, K

EIZAWA, H

SASE, K

INOUE, R

SUNAMOTO, M

ICHIMORI, Y

SATO, K

MORI, T

TAKAHASHI, K

KAWAI, C

SASAYAMA, S

YUI, Y

机构：

[1] KYOTO UNIV,FAC MED,DEPT INTERNAL MED 3,KYOTO 606,JAPAN

[2] TAKEDA CHEM IND LTD,PHARMACEUT RES DIV,OSAKA 532,JAPAN

[3] KUMAMOTO UNIV,SCH MED,DEPT PATHOL 2,KUMAMOTO 860,JAPAN

来源：

HYBRIDOMA | 1993年 / 12卷 / 06期

关键词：

D O I：

10.1089/hyb.1993.12.763

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have produced 14 monoclonal antibodies to inducible nitric oxide synthase purified from rat peritoneal cytotoxic activated macrophages. None of the antibodies showed neutralizing activity, but some of them enhanced the enzyme activity through stabilization of the enzyme.

引用

收藏

页码：763 / 770

页数：8

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