THE EFFECT OF CYCLOPHOSPHAMIDE PULSES ON FERTILITY IN PATIENTS WITH LUPUS NEPHRITIS

被引：58

作者：

LANGEVITZ, P

KLEIN, L

PRAS, M

MANY, A

机构：

[1] CHAIM SHEBA MED CTR, DEPT INTERNAL MED F, HEMATOL UNIT, IL-52621 TEL HASHOMER, ISRAEL

[2] SACKLER SCH MED, TEL AVIV, ISRAEL

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1992年 / 28卷 / 3-4期

关键词：

LUPUS NEPHRITIS; CYCLOPHOSPHAMIDE; FERTILITY;

D O I：

10.1111/j.1600-0897.1992.tb00780.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of cyclophosphamide pulse therapy given in relatively small doses (10 mg/kg per pulse) in 17 females with lupus nephritis has been studied. Four females developed menopause; in one transient amenorrhea occurred. No changes in menstrual cycle were noted in the other 11 females, four of whom subsequently delivered five normal babies. These data suggest the relative safety of small doses of cyclophosphamide pulse therapy on gonadal function in females under age 40 years.

引用

页码：157 / 158

页数：2

共 19 条

[1] THERAPY OF LUPUS NEPHRITIS - CONTROLLED TRIAL OF PREDNISONE AND CYTOTOXIC DRUGS [J].