A PEPTIDE FROM SCHUMANNIOPHYTON-MAGNIFICUM WITH ANTI-COBRA VENOM ACTIVITY

被引：16

作者：

HOUGHTON, PJ ^{[1
]}

OSIBOGUN, IM ^{[1
]}

BANSAL, S ^{[1
]}

机构：

[1] KINGS COLL LONDON, CHELSEA DEPT PHARM, PHARMACEUT CHEM RES LABS, LONDON SW3 6LX, ENGLAND

来源：

PLANTA MEDICA | 1992年 / 58卷 / 03期

关键词：

SCHUMANNIOPHYTON-MAGNIFICUM; RUBIACEAE; PEPTIDES; ANTI-SNAKE VENOM ACTIVITY;

D O I：

10.1055/s-2006-961449

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Using the chick biventer cervicis preparation as a bioassay for antivenom activity, a peptide has been isolated from the aqueous extract of the bark of Schumanniophyton magnificum. The peptide was isolated and purified by a combination of reverse-phase and exclusion column chromatography, preparative TLC, and HPLC. The peptide has a relative molecular mass of about 6000 daltons and is similar in amino acid composition to the cardiotoxins present in snake venom. The isolated peptide showed dose-related inhibitions of the effects of cardiotoxin and total venom of cobra species using the chick biventer cervicis preparation.

引用

页码：263 / 265

页数：3

共 6 条

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