SYNTHESIS OF A BIOCHEMICALLY IMPORTANT ALDEHYDE, 3,4-DIHYDROXYPHENYLGLYCOLALDEHYDE

被引：15

作者：

LI, SW

ELLIOTT, WH

BURKE, WJ

机构：

[1] VET ADM MED CTR,DEPT BIOCHEM,ST LOUIS,MO 63110

[2] ST LOUIS UNIV,CTR HLTH SCI,SCH MED,ST LOUIS,MO 63110

来源：

BIOORGANIC CHEMISTRY | 1994年 / 22卷 / 04期

关键词：

D O I：

10.1006/bioo.1994.1027

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

3,4-Dihydroxyphenylglycolaldehyde (DOPEGAL) is an important precursor of the major brain metabolites of noradrenaline, 3,4-dihydroxyphenyglycol, and 3-methoxy-4-hydroxyphenylglycol. Methods for the synthesis of DOPEGAL have been developed. The alpha-hydroxy and masked aldehyde groups were introduced simultaneously in one step. This method dan also be used for preparation of other metabolites of catecholamines. (C) 1994 Academic Press, Inc.

引用

页码：337 / 342

页数：6

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