SOLID-PHASE SYNTHESIS OF OLIGOETHERS - SOLUBLE POLYMER MODEL STUDIES

被引:6
作者
HENDERSON, HC
SHERRINGTON, DC
GOUGH, A
机构
[1] UNIV STRATHCLYDE,DEPT PURE & APPL CHEM,295 CATHEDRAL ST,GLASGOW G1 1XL,SCOTLAND
[2] UNILEVER RES,PORT SUNLIGHT LAB,BEBINGTON L63 3JW,ENGLAND
关键词
SYNTHESIS; OLIGOETHERS; NMR SPECTROSCOPY;
D O I
10.1016/0032-3861(94)90321-2
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A soluble chloromethylated polystyrene has been used as a support for the stepwise synthesis of oligoethers. The building block was the monotrityl ether of tetraethylene glycol, and coupling, deprotection, activation and elongation steps have been successfully developed. The progress of reactions has been demonstrated by elemental analysis of the polymer and FTi.r. spectral analysis. Most powerful, however, has been H-1 n.m.r. spectroscopy, made possible by the soluble nature of the polymer. While successive reactions on the polymer appear to be highly efficient, work-up and isolation inevitably result in loss of polymer mass, and preclude this from being a viable methodology for scale-up.
引用
收藏
页码:2867 / 2873
页数:7
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