Genetic polymorphisms of nerve growth factor receptor (NGFR) and the risk of Alzheimer ' s disease

被引：13

作者：

Cheng, Hui-Chi ^{[1
]}

Sun, Yu ^{[2
]}

Lai, Liang-Chuan ^{[3
]}

Chen, Shih-Yuan ^{[1
]}

Lee, Wen-Chung ^{[1
,4
,5
]}

Chen, Jen-Hau ^{[1
,6
]}

Chen, Ta-Fu ^{[7
]}

Chen, Hua-Hsiang ^{[1
]}

Wen, Li-Li ^{[8
]}

Yip, Ping-Keung ^{[9
]}

Chu, Yi-Min ^{[10
]}

Chen, Wei J. ^{[1
,4
,5
]}

Chen, Yen-Ching ^{[1
,4
,5
]}

机构：

[1] Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan

[2] En Chu Kong Hosp, Dept Neurol, Taipei, Taiwan

[3] Natl Taiwan Univ, Coll Med, Grad Inst Physiol, Taipei, Taiwan

[4] Res Ctr Genes Environm & Human Hlth, Taipei, Taiwan

[5] Natl Taiwan Univ, Coll Publ Hlth, Dept Publ Hlth, Taipei, Taiwan

[6] Natl Taiwan Univ Hosp, Dept Geriat & Gerontol, Taipei, Taiwan

[7] Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan

[8] En Chu Kong Hosp, Dept Lab Med, Taipei, Taiwan

[9] Cardinal Tiens Hosp, Ctr Neurol Med, Taipei, Taiwan

[10] Cardinal Tiens Hosp, Dept Lab Med, Taipei, Taiwan

来源：

JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE | 2012年 / 11卷

关键词：

NGFR; Alzheimer ' s disease; htSNP; haplotype;

D O I：

10.1186/1477-5751-11-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Background: Loss of basal forebrain cholinergic neurons is attributable to the proapoptotic signaling induced by nerve growth factor receptor (NGFR) and may link to Alzheimer's disease (AD) risk. Only one study has investigated the association between NGFR polymorphisms and the risk of AD in an Italian population. Type 2 diabetes mellitus (DM) may modify this association based on previous animal and epidemiologic studies. Methods: This was a case-control study in a Chinese population. A total of 264 AD patients were recruited from three teaching hospitals between 2007 to 2010; 389 controls were recruited from elderly health checkup and volunteers of the hospital during the same period of time. Five common (frequency >= 5%) haplotype-tagging single nucleotide polymorphisms (htSNPs) were selected from NGFR to test the association between NGFR htSNPs and the risk of AD. Results: Variant NGFR rs734194 was significantly associated with a decreased risk of AD [ GG vs. TT copies: adjusted odds ratio (OR) = 0.43, 95% confidence interval (CI) = 0.20-0.95]. Seven common haplotypes were identified. Minor haplotype GCGCG was significantly associated with a decreased risk of AD (2 vs. 0 copies: adjusted OR = 0.39, 95% CI = 0.17-0.91). Type 2 DM significantly modified the association between rs2072446, rs741072, and haplotype GCTTG and GTTCG on the risk of AD among ApoE epsilon 4 non-carriers (P-interaction < 0.05). Conclusion: Inherited polymorphisms of NGFR were associated with the risk of AD; results were not significant after correction for multiple tests. This association was further modified by the status of type 2 DM.

引用

页数：9

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