APOPTOTIC AND MITOTIC INDEXES IN MALIGNANT-MELANOMA AND BASAL-CELL CARCINOMA

被引：60

作者：

MOONEY, EE ^{[1
]}

PERIS, JMR ^{[1
]}

ONEILL, A ^{[1
]}

SWEENEY, EC ^{[1
]}

机构：

[1] ST JAMES HOSP,UNIV DUBLIN TRINITY COLL,DEPT HISTOPATHOL,DUBLIN 8,IRELAND

来源：

JOURNAL OF CLINICAL PATHOLOGY | 1995年 / 48卷 / 03期

关键词：

APOPTOSIS; MITOSIS; MELANOMA; BASAL CELL CARCINOMA;

D O I：

10.1136/jcp.48.3.242

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Aims-To assess the relative frequency of mitotic and apoptotic cells in malignant melanoma and basal cell carcinoma. Methods-Retrospective evaluation of haematoxylin and eosin stained slides from 10 basal cell carcinomas, 10 nodular melanomas, and 10 superficial spreading melanomas, with counting of apoptotic and mitotic cells per 1000 cells. Selected cases were studied with in situ end-labelling. Results-The ratio of apoptotic to mitotic cells was higher in basal cell carcinoma than in either form of melanoma because of the presence of a greater number of apoptotic cells in basal cell carcinoma. Conclusion-The differing growth rates and biological behaviour of these two tumours is reflected In the apoptotic:mitotic ratio. Further assessment of this ratio is warranted, both between tumour types and between individual tumours of one type, to determine its value as an indicator of biological potential.

引用

页码：242 / 244

页数：3

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