STRUCTURE AND PHYSIOLOGY OF PHOTORECEPTOR CGMP-GATED CATION CHANNELS

被引：1

作者：

HAYNES, LW

机构：

来源：

BEHAVIORAL AND BRAIN SCIENCES | 1995年 / 18卷 / 03期

关键词：

D O I：

10.1017/S0140525X00039315

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The primary sequence of two subunits of the rod and one subunit of the cone cGMP-gated channel have been described, but describing how structure determines function is only just beginning. The discovery that the affinity of the rod channel for its agonist can be modulated indicates that the relationship between intracellular cGMP and the channel's open probability (current) during the course of the photoresponse may be more complex than previously thought.

引用

收藏

页码：476 / 477

页数：2

相关论文

共 7 条

[1] A NEW SUBUNIT OF THE CYCLIC NUCLEOTIDE-GATED CATION CHANNEL IN RETINAL RODS [J].

CHEN, TY ;

PENG, YW ;

DHALLAN, RS ;

AHAMED, B ;

REED, RR ;

YAU, KW .

NATURE, 1993, 362 (6422) :764-767

[2] PROTEIN PHOSPHATASES MODULATE THE APPARENT AGONIST AFFINITY OF THE LIGHT-REGULATED ION CHANNEL IN RETINAL RODS [J].

GORDON, SE ;

BRAUTIGAN, DL ;

ZIMMERMAN, AL .

NEURON, 1992, 9 (04) :739-748

[3] THE EFFECT OF RECOVERIN-LIKE CALCIUM-BINDING PROTEINS ON THE PHOTORESPONSE OF RETINAL RODS [J].

GRAYKELLER, MP ;

POLANS, AS ;

PALCZEWSKI, K ;

DETWILER, PB .

NEURON, 1993, 10 (03) :523-531

[4] BLOCK OF THE CYCLIC-GMP GATED CHANNEL OF VERTEBRATE ROD AND CONE PHOTORECEPTORS BY L-CIS-DILTIAZEM [J].

HAYNES, LW .

JOURNAL OF GENERAL PHYSIOLOGY, 1992, 100 (05) :783-801

[5] MODULATION OF THE CGMP-GATED CHANNEL OF ROD PHOTORECEPTOR CELLS BY CALMODULIN [J].

HSU, YT ;

MOLDAY, RS .

NATURE, 1993, 361 (6407) :76-79

[6] PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION FROM COMPLEMENTARY-DNA OF THE ROD PHOTORECEPTOR CYCLIC GMP-GATED CHANNEL [J].

KAUPP, UB ;

NIIDOME, T ;

TANABE, T ;

TERADA, S ;

BONIGK, W ;

STUHMER, W ;

COOK, NJ ;

KANGAWA, K ;

MATSUO, H ;

HIROSE, T ;

MIYATA, T ;

NUMA, S .

NATURE, 1989, 342 (6251) :762-766

[7] CYCLIC GMP-ACTIVATED CONDUCTANCE OF RETINAL PHOTORECEPTOR CELLS [J].

YAU, KW ;

BAYLOR, DA .

ANNUAL REVIEW OF NEUROSCIENCE, 1989, 12 :289-327