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SIMPLE, SENSITIVE METHOD FOR MEASURING 3,4-DIHYDROXYPHENYLACETIC ACID AND HOMOVANILLIC-ACID IN RAT-BRAIN TISSUE USING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION

被引：83
作者：
HEFTI, F
机构：
[1] Laboratory of Neuroendocrine Regulation Department of Nutrition, Food Science Massachusetts Institute of Technology Cambridge
来源：
LIFE SCIENCES | 1979年 / 25卷 / 09期
基金：
美国国家航空航天局; 美国国家卫生研究院;
关键词：
D O I：
10.1016/0024-3205(79)90522-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A sensitive, specific, and very simple method, using high-performance liquid chromatography combined with electrochemical detection, measured 3,4-dihydroxyphenylacetic acid and homovanillic acid in small areas of rat brain. The dopamine metabolites were extracted with diethyl ether and a known amount of vanillic acid as internal standard, and were separated on a micro-particulate reverse-phase column using a sodium acetate buffer (pH 5.0) as mobile phase. © 1979.
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页码：775 / 781
页数：7
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