MK-801 AMELIORATES DELAYED AMNESIA, BUT POTENTIATES ACUTE AMNESIA INDUCED BY CO

被引：24

作者：

NABESHIMA, T

YOSHIDA, S

MORINAKA, H

KAMEYAMA, T

THURKAUF, A

RICE, KC

JACOBSON, AE

MONN, JA

CHO, AK

机构：

[1] NIADDKD,BETHESDA,MD 20892

[2] UNIV CALIF LOS ANGELES,MED CTR,DEPT PHARMACOL,LOS ANGELES,CA 90024

来源：

NEUROSCIENCE LETTERS | 1990年 / 108卷 / 03期

关键词：

Carbon monoxide-induced amnesia; Delayed amnesia; Hypoxia; Memory; MK-801; Passive avoidance task; Phencyclidine;

D O I：

10.1016/0304-3940(90)90661-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of non-competitive N-methyl-d-aspartate receptor antagonists on amnesia induced by carbon monoxide (CO) were investigated, since they have neuroprotective effects on delayed degeneration induced by ischemia. In the mice exposed to CO, acute and delayed amnesia were induced. (+)-MK-801 and (-)-MK-801 improved the delayed amnesia, but the effects of phencyclidine (PCP) were weak. (+)-MK-801 and PCP potentiated the acute amnesia. From these results, it is suggested that there is a stereoselectivity in the effects of MK-801 on CO-induced amnesia and that CO-induced delayed amnesia animals could be used as an ischemic amnesia model. © 1990.

引用

页码：321 / 327

页数：7

共 13 条

[1] DELAYED MEMORY DYSFUNCTION BY TRANSIENT HYPOXIA, AND ITS PREVENTION WITH FORSKOLIN [J].